Mammalian Toxicology
Considerable legislation has been developed to protect people and the environment from the toxic effects of chemicals. Acute and subchronic toxicity testing provides fundamental data for evaluating products to inform both manufacturers and the public of potential hazards. Industries of significant economic and societal importance depend on safe use of effective chemicals.

STILLMEADOW, Inc. takes pride in its ability to provide the toxicology services needed for premanufacture notifications, registration of pesticides, labeling and consumer and employee purposes, following USEPA, OECD, OPPTS, and FDA guidelines.

Acute Studies
  • Acute Oral Toxicity in Rats Up and Down Method ( OPPTS 870.1100, OECD 425 )
  • Traditional Acute Oral Toxicity in Rats (OPPTS 870.1100, OECD 401)
  • Acute Dermal Toxicity in Rabbits or Rats (OPPTS 870.1200, OECD 402 )
  • Acute Inhalation Toxicity in Rats (OPPTS 870.1300, OECD 403)
  • Acute Eye Irritation in Rabbits (OPPTS 870.2400, OECD 405)
  • Acute Dermal Irritation in Rabbits (OPPTS 870.2500, OECD 404)
  • Skin Sensitization Studies
    -Guinea Pig - Buehler Method (OPPTS 870.2600, OECD 429)
    -Guinea Pig - Magnusson Kligman Method
    -Mouse - Local Lymph Node Assay (OPPTS 870.2600, OECD 429)
Subchronic Studies
  • 28 and 90-Day Oral Toxicity in Rats or Dogs
  • 90 Day Dermal Toxicity in Rats
  • 21 and 90-Day Dermal Toxicity in Rabbits
  • 28 and 90-Day Inhalation Toxicity in Rats
MPCA Studies
  • Acute Oral Toxicity/Infectivity
  • Acute Dermal Toxicity/Irritation
  • Pulmonary Toxicity/Infectivity
  • Acute Injection Toxicity/Infectivity
Preclinical Development
FDA approval of your Investigational New Drug (IND) application is the result of a successful preclinical development program, which begins with STILLMEADOW, Inc.

From guidance in the creation of unique pilot studies and protocols, to evaluation of the safety and efficacy of your product, STILLMEADOW Inc.’s experienced Study Directors and Laboratory Technicians support your Product Development Team in meeting FDA guidelines for advancement to clinical trials.
  • Pharmacokinetic (PK) analysis of drug absorption, distribution, metabolism and excretion (ADME)
  • Acute and subchrinic toxicological parameters
  • Dose range-finding studies
  • Complete heamtology and serum chemistry
  • Multiple Species
  • Creation of unique pilot studies and protocols to meet FDA guidelines
STILLMEADOW, Inc. performs pre-clinical Safety and Efficacy Studies, Pharmacokinetic Studies, and ADME (Adsorption, Distribution, Metabolism and Excretion) Studies.

Pre and Post Tox analyses are available in the absence of a Certificate of Analysis.
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