Avian Dietary Toxicology
STILLMEADOW, Inc. specializes in conducting avian toxicology testing according to EPA OCSPP Ecological Effects Test Guidelines. We conduct GLP non-target guideline avian testing with test substance administration by oral, inhalation and dietary routes using both terrestrial species ,bobwhite quail, and water fowl species, mallard duck. We conduct Avian Oral Toxicity Tests with microbials and biopesticides (885.4050), and conventional chemicals (850.2100). We do the Avian Dietary Toxicity Test (850.2200) and Avian Inhalation Test according to guideline (885.4100). Bobwhite quail is the most common species required by the regulatory agencies that we test with.
To ensure the highest quality of birds are available for testing that meet OCSPP avian toxicology guideline requirements, we incubate only disease-free certified eggs, which also ensures that we meet the requirement that all chicks used on a study come from the same egg hatch.
Avian Dietary Toxicity Test (850.2200) is conducted with chicks that must be 10-14 days old at dosing. The chicks are administered the test substance ad libitum as part of their diet in their feed for 5 days and then administered untreated feed for 3 days. A control group is fed untreated diet continuously for comparison.
- Limit test: A limit test consist of 10 chicks administered the diet containing the test substance mixed at 5000 ppm and a control group of 10 chicks are administered untreated diet.
- Definitive test: A definitive test consists of five groups of 10 chicks per group dosed with ten-fold serial dilutions of the diet containing the test substance to determine the NOEL and LC50.