Toxicity Testing

STILLMEADOW, Inc. specializes in toxicity testing.

We are an independent toxicity testing contract research facility. We are AAALAC Accredited and certified with the National Environmental Laboratory Accreditation Program (NELAP).

Our toxicity testing specialists have provided full-service, lab-certified evaluations since 1975 in the areas of drug development, mammalian and environmental toxicology, animal health, entomology, analytical services, and in vitro studies.

We were certified by the Japanese Ministry of Agriculture, Forestry and Fisheries (JMAFF) in 1992. In addition, key members of our toxicity testing staff are members of the Society of Quality Assurance, the Chemical Producers and Distributors Association, and the Society of Toxicology.

The toxicity testing Quality Assurance Unit (QAU) at STILLMEADOW, Inc. assures regulatory compliance by auditing studies, reviewing protocols, Standard Operating Procedures (SOPs), consulting with study directors, and interacting with sponsors. The QAU conducts regulatory training classes, hosts regulatory as well as sponsor inspections, and assesses subcontractor compliance.

The Quality Assurance Unit carries out report and data audits, facility inspections, and in-process inspections for compliance with:

  • Good Laboratory Practices (EPA, FDA, OECD, and JMAFF)
  • National Pollutant Discharge Elimination System (NPDES) under the Clean Water Act
  • Texas Pollutant Discharge Elimination System (TPDES)
  • Resource Conservation and Recovery Act (RCRA)
  • Toxic Substances Control Act (TSCA)
  • Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
  • International regulations for EU, OSPAR, etc.

Our staff are members of the following associations:

Society of Quality Assurance

Council of Producers & Distributors of Agrotechnology

Society of Environmental Toxicology and Chemistry (SETAC)

Society of Toxicology

Association for Assessment and Accreditation of Laboratory Animal Care International

And other associations and organizations.

For drug development, FDA approval of your Investigational New Drug (IND) application is the result of a successful drug development program, which begins with STILLMEADOW, Inc.

From guidance in the creation of unique pilot studies and protocols, to evaluation of the safety and efficacy of your product, STILLMEADOW, Inc.’s experienced study directors and laboratory technicians support your drug development in meeting FDA guidelines for advancement to clinical trials.

  • Pharmacokinetic (PK) analysis of drug absorption, distribution, metabolism and excretion (ADME)
  • Acute and subchronic toxicological parameters
  • Dose range-finding studies
  • Multiple species
  • Creation of unique pilot studies and protocols to meet FDA guidelines

STILLMEADOW, Inc. performs pre-clinical safety and efficacy studies, pharmacokinetic studies, and ADME (adsorption, distribution, metabolism and excretion) studies.

For Toxicology in Mammals, Avian, Fish, Reptiles and Insects: Considerable legislation has been developed to protect people and the environment from possible harmful effects of chemicals biopesticides, pharmaceuticals, and microbial pest control agents (MPCA’s). Acute and subchronic toxicity testing protocols provide fundamental data for evaluating products to inform both manufacturers and the public of potential hazards. Industries of significant economic and societal importance rely on safe use of effective chemicals for a multitude of useful and beneficial purposes. STILLMEADOW, Inc. takes pride in its ability to provide the toxicology services needed for premanufacture notification, registration of pesticides, labeling and safe handling recommendations for consumers and employees.

For Animal Health we specialize in companion and farm animals.

Our Analytical Services include:

Chemistry

    • Preliminary Analysis
    • 5 Batch Analysis
    • Color, Physical State, Odor
    • Density or Specific Gravity
    • pH testing
    • Oxidizing and Reducing Action
    • Flammability and Explodability
    • Method Validation
    • Storage Stability and Corrosion Characteristics
    • Viscosity and Miscibility
    • Dielectric Breakdown Voltage
    • Melting Point, Boiling Point and Pour Point
    • Vapor Pressure
    • Dissociation Constant and Solubility
    • Octanol/Water Partition Coefficient
    • UV/Visible Absorption
    • Stability
    • Analytical Enforcement Method

    Environmental Fate

    • Hydrolysis Studies
    • Aqueous Photolysis
    • Soil Photolysis
    • Aerobic and Anaerobic Aquatic
    • Leaching (Parent and Aged)
    • Method Development and Identification Analysis
    • Ready Biodegradability

    Pharmacokinetic/Toxicokinetic Studies

    • PK studies using radio labeled compounds or trace analyses
    • Absorption, Distribution, Metabolization, and Excretion (ADME)
    • Support for preclinical efficacy and safety studies
    • Metabolite analysis

    Guidelines

    • Good Laboratory Practices
    • EPA FIFRA Subdivision D
    • OPPTS
    • DOT, OECD, TSCA
    • AOAC
    • ASTM
    • CIPAC
    • NRC licensed

    Analytical Equipment

    • Gas Chromatography (GC) with Flame Ionization Detector (FID) and Mass Spectrometer (MS)
    • Liquid Chromatography (HPLC) with Diode Array (DAD), Charged Aerosol (CAD), Fluorescence Detector and MS
    • Ion Chromatography (IC) with Ion Conductivity Detector and Electrochemical Detector
    • UV/VIS Spectrophotometer
    • Metrohm 916 Ti-Touch Potentiometric autotitrator
    • Metrohm 915 KF Ti-Touch autotitrator for water content analysis, Karl Fischer
    • Liquid Scintillation Analyzer
    • Refrigerated Automatic Centrifuge
    • Melting Point Apparatus
    • Impact Explodability Apparatus
    • Dielectric Breakdown Voltage Voltmeter
    • Multipycnometer
    • Differential Scanning Calorimeter
    • Coulter Counter
    • Tyler Sieve Shaker
    • Rotary Evaporator
    • Biological Oxidizer OX 600
    • Dissolved Oxygen Meter
    • Flashpoint/Fire Point Tester
    • Rotational Viscometer
    • Surface Tensiometer / Micelle Concentration

To report an Animal Welfare concern click on this link and submit the form.

Our toxicity testing corporate headquarters are in Sugar Land, Texas, southwest of Houston. With 3 buildings and more than 75,000 square feet of space, we have the capacity to conduct many types of studies concurrently and hope to partner with you soon.

Contact us now for your toxicity testing needs!

Our toxicity testing facility has the most up to date equipment.

In addition to toxicity testing we pride ourselves on overall testing of various materials.

The reporting of toxicity testing is accepted by most governmental agencies worldwide.

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